2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-G0011
    Netupitant metabolite Netupitant N-oxide
    Netupitant N-oxide is the metabolite of Netupitant, which is a highly selective NK1 receptor antagonist.
    Netupitant metabolite Netupitant N-oxide
  • HY-W349628
    Dibutyl 3-hydroxybutyl phosphate
    Dibutyl 3-hydroxybutyl phosphate is a predominant metabolite of tris( n-butyl) phosphate (TNBP). TNBP is a commonly used alkyl organophosphate ester.
    Dibutyl 3-hydroxybutyl phosphate
  • HY-129883
    (3R)-Hydroxyquinidine
    (3R)-Hydroxyquinidine is the major metabolite of Quinidine (HY-B1751).
    (3R)-Hydroxyquinidine
  • HY-W015169S
    5-Methoxytryptamine-d4
    5-Methoxytryptamine-d4 (O-Methylserotonin-d4) is the deuterium labeled 5-Methoxytryptamine (HY-W015169). 5-Methoxytryptamine, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine is also a potent antioxidant and has radioprotective action.
    5-Methoxytryptamine-d<sub>4</sub>
  • HY-W015332R
    Captopril EP Impurity D (Standard)
    Captopril EP Impurity D (Standard) is the analytical standard of Captopril EP Impurity D. This product is intended for research and analytical applications. Captopril EP Impurity D is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM).
    Captopril EP Impurity D (Standard)
  • HY-Z8447
    9(E)-Erythromycin A oxime
    		Control
    (9E)-Erythromycin A oxime is a metabolite of Roxithromycin (HY-B0435). Roxithromycin is a semi-synthetic macrolide antibiotic.
    9(E)-Erythromycin A oxime
  • HY-118788
    N-Desmethyl rosiglitazone
    N-Desmethyl rosiglitazone (SB 237216) is a metabolite of Rosiglitazone (HY-17386), generated through demethylation by the cytochrome P450 enzyme system in liver microsomes. It retains partial PPARγ agonist activity and supports studies on the metabolism and pharmacokinetics of Rosiglitazone (HY-17386).
    N-Desmethyl rosiglitazone
  • HY-W588248
    DL-Sulforaphane glutathione
    DL-Sulforaphane glutathione (DL-SFN-GSH) is a metabolite of Sulforaphane (HY-13755) in rat plasma.
    DL-Sulforaphane glutathione
  • HY-W716865
    CBNQ
    CBNQ (Compound 22; Cannabinolquinone; HU-345) is an oxidative product of cannabinol.
    CBNQ
  • HY-Z18056
    Norpropranolol hydrochloride
    Norpropranolol hydrochloride is the active metabolite of Propranolol (HY-B0573B).
    Norpropranolol hydrochloride
  • HY-W107263
    4-Hydroxypentanoate sodium
    		Control
    4-Hydroxypentanoate sodium, a sedative, is an active metabolite of gamma-Valerolactone (HY-W015938).
    4-Hydroxypentanoate sodium
  • HY-167638
    Fenretinide glucuronide
    Fenretinide glucuronide (4-HPR-O-glucuronide) is a metabolite formed from Fenretinide (HY-15373) through glucuronidation. The formation of Fenretinide glucuronide enhances the water solubility of Fenretinide and facilitates its excretion. Fenretinide glucuronide holds potential for research in the field of cancer.
    Fenretinide glucuronide
  • HY-Z2338
    5-O-Desmethyl omeprazole
    5-O-Desmethyl omeprazole is a metabolite of Omeprazole by cytochrome P450.
    5-O-Desmethyl omeprazole
  • HY-G0006R
    Omeprazole sulfide (Standard)
    Omeprazole sulfide (Standard) is the analytical standard of Omeprazole sulfide. This product is intended for research and analytical applications. Omeprazole sulfide is an Esomeprazole (HY-17021) precursor. Omeprazole sulfide can be converted to Esomeprazole by Lysinibacillus sp. B71. Esomeprazole can inhibit gastric H+/+ ATP enzyme. Omeprazole sulfide is mainly used in gastroesophageal reflux disease, gastric ulcer and antibacterial research.
    Omeprazole sulfide (Standard)
  • HY-131272R
    Febuxostat dicarboxylic acid impurity (Standard)
    Febuxostat dicarboxylic acid impurity (Standard) is the analytical standard of Febuxostat dicarboxylic acid impurity. This product is intended for research and analytical applications. Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat dicarboxylic acid impurity (Standard)
  • HY-129903R
    N-Desethyl vardenafil (Standard)
    N-Desethyl vardenafil (Standard) is the analytical standard of N-Desethyl vardenafil. This product is intended for research and analytical applications. N-Desethyl vardenafil is the major metabolite of Vardenafil (HY-B0442) and can be detected in human urine.
    N-Desethyl vardenafil (Standard)
  • HY-171459
    LEQ803
    LEQ803 (N-Desmethyl Ribociclib) is a drug metabolite of the CDK4/6 inhibitor Ribociclib (HY-15777), which is produced through metabolism by CYP3A4. LEQ803 has potential application value in the field of oncology.
    LEQ803
  • HY-130569S1
    7-Hydroxymethotrexate-d3
    7-Hydroxymethotrexate-d3 is the deuterium labeled 7-Hydroxymethotrexate. 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1][2].
    7-Hydroxymethotrexate-d<sub>3</sub>
  • HY-135407S
    N-Desethyl Oxybutynin-d5 hydrochloride
    N-Desethyl Oxybutynin-d5 (hydrochloride) is deuterium labeled N-Desethyl Oxybutynin hydrochloride. N-Desethyl Oxybutynin is the the active metabolite Oxybutynin. Oxybutynin is an anticholinergic agent that inhibits voltage-dependent K+ channels.
    N-Desethyl Oxybutynin-d<sub>5</sub> hydrochloride
  • HY-W010143
    (R,S)-Norcotinine
    (R,S)-Norcotinine ((Rac)-Norcotinine) is the racemic mixture of Norcotinine. (R,S)-Norcotinine is a biomarker of secondhand smoke exposure and is associated with the toxic mechanisms of secondhand smoke on cardiovascular development.
    (R,S)-Norcotinine
Cat. No. Product Name / Synonyms Application Reactivity